THE BLOCKING EFFECT OF PHYLLANTHUS EMBLICA L.ON THE FORMATION OF STRONG CARCINOGEN N-NITROSO COMPOUND IN HUMAN BODY

The paper deals with the blocking effect of Phyllanthus emblica L.on the formation of N-nitroso-compound in human body.Ohshima's method was used to measure the quantity of N-nitroso-proline (NPRO) in urine as an index.Each one of the twelve tested men absorbed 500 mgL- proline and 300 mg sodium nitrate,after that,the average quantity of N-nitroso-proline in their urine was 75.10nmol.However,when absorbing L-proline and sodium nitrate,they absorbed again ascorbic acid and Phyllanthus emblica L.juice of the same concentration with ascorbic acid separately.The content of NPRO in their urine was down to 41.08nmol and 20.79nmol respectively.The content of NPRO of the latter is lower than background number (25.55 nmol).It indicated that if a man absorbed 13ml Phyllanthus emblica L.juice containing 75 mg ascorbic acid in this experiment,the synthesis of NPRO,which was formed by absorbing 500 mgL- proline and 300 mg sodium nitrate in human body could be blocked.Besides,it also showed that the Phyllanthus emblica juice could block the synthesis of N-nitroso-compound in human body effectively.