The Preliminary Study on Biological Activity of Synthetic Philanthotoxin Analogs
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1.
The College of Agronomy, Xinjiang Agricultural University, Urumqi 830052, Xinjiang, China
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2.
Research Institute of Forest Ecology, Environment and Protection, CAF, Key Laboratory of Forestry Protection, State Forestry Administration, Beijing 100091, China
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3.
Research Institute of Forest Ecology, Environment and Protection, CAF, Key Laboratory of Forestry Protection, State Forestry Administration, Beijing 100091, China
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4.
School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081, China
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Received Date:
2005-08-09
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Abstract
This paper reported the biological activities of five synthetic philanthotoxin analogs.Trials under laboratory condition indicated a certain level of activity on poisoning and inhibiting emergence rate.The LC50 of compound 1 on Ectropis obliqua was 8.987×103 mg·L-1.At the 8×103 mg·L-1 dosage of compound 1,the adjustment rate of pupation and emergence of E.obliqua was 52.44% and 89.81% respectively.The compound 2 had a certain effect on the larval and pupal weight.
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References
|
[1]
|
R thm ayerW. Paralysis cased by the d iggerw aspP hi lan thus triangulum [J] . Natu re (London) , 1962, 196: 1148 ~ 1151 |
|
[2]
|
P iek T. The effect of the venom of the digger w aspPh ilanthu s triangu lum F. on the fast and slow excitatory and inh ib itory sys tem in thelocust muscle[J] . Experient ia, 1966, 12: 462 ~ 463 |
|
[3]
|
Span jerW, M ay T E, P iek T, et a.l Part ial pu rif icat ion of componen ts from th e p ara lyzing venom of the digger w aspPh ilanthu s triangu lum F. and their action[J] . Com p B iochem Physio,l 1982, 71C:149~ 157 |
|
[4]
|
M ay T E, P iek T. Neuronmu scu lar b lock in locus t sk eletalm usclecaused by the venom p reparationm ade from the d iggerw asp Ph ilanthu s triangulum [J] . J Insect Phys io,l 1979, 25: 685 ~ 691 |
|
[5]
|
P iek T. Delta-ph ilanthotoxin, a sem i-irreversible block er of ionch ann els[J] . Com p B ioch em Physio,l 1982, 72: 311 ~ 315 |
|
[6]
|
An is N A, Sherby S, Goodnow R A, et a.l S tructu re-act ivity relationsh ip s of ph ilanthotoxin analogs and n icotin ic acetylch oline receptors [J] . J Pharmacol Exp Th er, 1990, 254: 764 ~ 773 |
|
[7]
|
B ruceM, Buk own ikR , U sh erw ood P N R, et a.l Stru cture-activityrelat ionsh ips of analogu es of the w asp tox in ph ilanthotoxin: non-competit ive antagon ists of qu isqualate receptors[J] . Toxicon, 1990, 28:1333 ~ l346 |
|
[8]
|
Choi S-K, Nakan ish i K, Usherw ood P N R. Label ling stud ies ofphoto lab ile ph ilan th toxin s w ith n icotin ic acetylch oline receptors:m ode of in teraction betw een toxin and receptor [J] . Chem B io,l1995, 2: 23 ~ 32 |
|
[9]
|
Nakan ish i K, Goodnow R, Konno K, et a.l Ph ilan thotoxin-433(PhTX-433) , a N on-com petit ive G lutam ate Receptor Inh ib itor[J] .Pu re& App l Chem, 1990, 62: 1223 ~ 1230 |
|
[10]
|
Ch oiS-K, Nak an ish iK, U sherw ood P N R. Synthes is and assay ofhybrid an alogs of arg iotoxin-636 and ph ilan thotoxin-433: Glutam atereceptor antagon ists[J] . Tetrah edron, 1993, 49: 5777~ 5890 |
|
[11]
|
Brackley P T H, BellD-R, C ho iS-K, et a.l Select ive an tagon ism ofnat ive and cloned kainate and NMDA receptors by polyam ine con ta ining toxin s[J] . J Pharm acolExp Th er, 1993, 266: 1573~ l580 |
|
[12]
|
F inney D J. Prob itAn alysis, 3 rd ed. [M] . London: C amb ridge Un ivers ity Press, 1977 |
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Proportional views
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